Accelerated biological aging and incident degenerative valvular heart disease: Findings from 408,783 UK Biobank participants.

ABSTRACT:

Background

Although prior studies have linked frailty and accelerated biological aging to aortic stenosis, comprehensive evidence across the spectrum of degenerative valvular diseases (VHD) and related clinical events remains unclear in middle-aged adults.

Methods

We analyzed 408,783 UK Biobank participants free of baseline valvular disease. Biological age accelerations (BAA) measures were derived from clinical traits using Phenotypic Age (PhenoAge) algorithm and the Klemera-Doubal method Biological Age (KDM-BA). Outcomes included incident aortic stenosis (AS), aortic regurgitation (AR), mitral regurgitation (MR), and related interventions or mortality.

Results

Over a median follow-up of 13.9 years, 10,364 incident degenerative VHD events (2.5 %) were documented, comp

SUBMITTER: Lin C 

PROVIDER: S-EPMC12662120 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature