Deuterium Metabolic Imaging of the Human Abdomen at Clinical Field Strength.

ABSTRACT:

Objectives

The aim of the study was to translate abdominal deuterium metabolic imaging (DMI) to clinical field strength by optimizing the radiofrequency coil setup, the administered dose of deuterium ( 2 H)-labeled glucose, and the data processing pipeline for quantitative characterization of DMI signals over time. This was assessed in the kidney and liver to establish a basis for routine clinical studies in the future.

Materials and methods

5 healthy volunteers were recruited and imaged on 2 or 3 separate occasions, with varying doses of 2 H-glucose: 0.75 g/kg (high dose), 0.50 g/kg (medium dose), and 0.25 g/kg (low dose), resulting in a total of 13 DMI scan sessions. DMI was performed at 3 T using a flexible 20 × 30 cm 2 2 H-tuned transmit-receive surface coil. For quantit

SUBMITTER: Wodtke P 

PROVIDER: S-EPMC12662132 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature