The dltC gene contributes to polyhexamethylene biguanide resistance in <i>Staphylococcus aureus</i>.

ABSTRACT: As the efficacy of conventional antibiotics continues to decline due to antibiotic resistance, there is an urgent need for alternative antimicrobial strategies. Polyhexamethylene biguanide (PHMB), a cationic polymer with broad-spectrum antimicrobial activity and low toxicity, has been extensively used in medical and personal care applications. Although no definitive cases of bacterial resistance to PHMB have been reported, resistance to other cationic agents suggests the potential resistance to PHMB. In this study, Staphylococcus aureus was cultivated in the presence of a sublethal concentration of PHMB for 30 days, during which the organism developed inheritable resistance. A quantitative proteomics study identified differential expression of the DltC protein, which is associated w

SUBMITTER: Guo C 

PROVIDER: S-EPMC12662226 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature