Key genes associated with the comorbidity of allergic rhinitis and chronic rhinosinusitis with nasal polyps: Identification, experimental validation, and an observational study using transcriptomic profiling and Mendelian randomization analysis in humans.

ABSTRACT: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) frequently coexists with allergic rhinitis (AR). However, the underlying connection between these 2 conditions remains poorly understood. This study aimed to identify and validate key comorbidity genes associated with both AR and CRSwNP, providing novel therapeutic targets and strategies. Transcriptomic data related to AR and CRSwNP were analyzed. Key comorbidity genes were 1st identified through differential expression analysis in the GSE19190 and GSE136825 datasets, Mendelian randomization studies for AR and CRSwNP, and gene expression analysis in AR-related datasets (GSE19190, GSE46171), and CRSwNP-related datasets (GSE136825, GSE179265). Subsequent functional enrichment, immune infiltration, and drug prediction analyses were condu

SUBMITTER: Hu X 

PROVIDER: S-EPMC12662326 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature