Investigating the genetic causality between periodontitis and intracranial aneurysms: A 2-sample Mendelian randomization study.

ABSTRACT: Previous studies have suggested an association between periodontitis and intracranial aneurysms (IAs). However, it remains unclear whether the association is causal. This study systematically investigated the potential genetic link between periodontitis and IAs, including the formation and rupture of IAs. This study utilized publicly available genome-wide association study summary statistics data for a 2-sample bidirectional Mendelian randomization (MR) analysis. The main statistical analysis method used was inverse variance weighting. The reliability of the results was verified through sensitivity analysis and assessment of the strength of genetic instrumental variables. There was no causal relationship between genetically determined periodontitis and uIAs (odds ratio [OR] = 1.02, 95% con

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12662415 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature