Causal effects between gut microbiota and coronary heart disease: A Mendelian randomization study.

ABSTRACT: Therapeutic interventions targeting gut microbiota (GM) are promising strategies for the prevention and treatment of coronary heart disease (CHD). Numerous studies have demonstrated a correlation between the GM and CHD. However, these findings do not describe a causal relationship between GM and CHD. Using a bidirectional 2-sample Mendelian Randomization (MR) analysis approach, we utilized a genome-wide association study dataset from the MiBioGen Consortium (N = 18,340) and CHD data from the CARDIoGRAMplusC4D 1000 Genome-based genome-wide association study meta-analysis (60,801 cases and 123,504 controls) to investigate the causal link between GM and CHD. Methods such as inverse-variance weighted, MR-Egger, weighted median, and weighted mode were used to assess causality. Sensitivity analy

SUBMITTER: Chen H 

PROVIDER: S-EPMC12662416 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature