Identification of ferroptosis-related therapeutic targets and causal risk factors in aortic dissection via multi-omics integration.

ABSTRACT: The role of ferroptosis in the pathogenesis of aortic dissection (AD) has not been fully clarified. Data from the gene expression omnibus database were analyzed to identify differentially expressed ferroptosis-related genes (FRGs) in AD. Key FRGs were selected using Least Absolute Shrinkage and Selection Operator regression and validated with receiver operating characteristic analysis. Single-cell RNA sequencing was applied to assess expression patterns in specific cell types. Mendelian randomization was further performed using genome-wide association study summary statistics for 211 gut microbial taxa and 1400 serum metabolites to explore causal associations with AD. A total of 14 differentially expressed FRGs were identified. Among them, 7 genes (CHAC1, CDO1, HILPDA, GSK3B, DPEP1, BRD4,

SUBMITTER: Peng S 

PROVIDER: S-EPMC12662444 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature