Identification of differential expressed genes common to rheumatoid arthritis and osteoporosis based on GEO database.

ABSTRACT: Rheumatoid arthritis (RA) and osteoporosis (OP) are both immune-mediated inflammatory diseases with similar clinical manifestations. A number of studies have shown that there is some correlation between RA and OP. But the mechanism between RA and OP has not been explored. Therefore, this article aims to explore the hub genes and the differentially expressed genes of RA and OP. We selected GSE55235 and GSE35959 from the Gene Expression Omnibus (GEO) database for the difference analysis. We used the GEO2R in GEO database for screening differentially expressed genes and Metascape for enrichment analysis. The protein-protein interaction network and hub genes were identified using the STRING 11.5 database and Cytoscape (version 3.7.2). Subsequently, build diagnostic models with hub genes. In GS

SUBMITTER: Chen L 

PROVIDER: S-EPMC12662563 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature