Global emergence of <i>Acinetobacter baumannii</i> International Clone 12 predominantly found in the Middle East.

ABSTRACT: Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are of great concern, as mortality is high, and treatment options are very limited. Despite having among the highest rates reported worldwide, scarce genomic data are available on CRAB strains from the Middle East. Here, we report the global emergence of a novel International Clone (IC), designated IC12, based on the epidemiological, phenotypic and genome sequencing data (short reads and long reads) of a set of 60 A. baumannii isolates belonging to multilocus sequence type 158 (Pasteur scheme). IC12, prevailing in the Middle East since 2007, has also been found in Europe, Asia and South America. Alleles OXA-65 and ADC-117, coded by the bla _OXA-51-like and bla _ADC

SUBMITTER: Karah N 

PROVIDER: S-EPMC12662599 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature