Aberrant MicroRNA-124 expression and methylation in the dorsolateral prefrontal cortex of depressed subjects.

ABSTRACT: Major depressive disorder (MDD) is a prevalent psychiatric illness and a leading cause of suicide. Genetics and epigenetics play crucial roles in MDD pathogenesis. Among the epigenetic regulators, microRNAs (miRNAs) have gained significant attention for their ability to modulate gene expression post-transcriptionally, making them promising therapeutic targets. Previous research from our group identified brain-enriched miR-124-3p as a key regulator of MDD by targeting the glucocorticoid receptor, a crucial mediator of stress responses. However, the precise regulation of miR-124-3p in MDD, including its potential gender-specific expression patterns, remains unclear. This study aimed to investigate the role of miR-124-3p in MDD by addressing whether: 1) miR-124-3p expression is dysregulated i

SUBMITTER: Funahashi Y 

PROVIDER: S-EPMC12662661 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature