Development and Validation of a Green Analytical Method for Calcium Determination in Pharmaceuticals Using Curcumin: A Sustainable Approach.

ABSTRACT:

Background

Reliable determination of calcium in pharmaceuticals is crucial for quality control, yet conventional methods often rely on synthetic chelating agents such as EDTA, which raise environmental and safety concerns. Curcumin, the principal polyphenolic compound in Curcuma longa (turmeric), exhibits strong metal-chelating properties through its β-diketone structure. This study explores the use of curcumin as a natural and sustainable chelating agent for the spectrophotometric determination of calcium in pharmaceutical formulations.

Method

Curcumin was extracted from turmeric rhizomes collected from different altitudes in Nepal using ethanol and was allowed to form a stable color complex with various calcium-containing drugs, such as calcium gluconate, calcium la

SUBMITTER: Dangi NB 

PROVIDER: S-EPMC12662665 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature