Epidemiologic Trends and Factors Associated With Overall Survival for Patients With Hepatobiliary Neuroendocrine Neoplasms in the United States.

ABSTRACT:

Background

Neuroendocrine neoplasms (NENs) constitute a heterogeneous group of rare tumors that most commonly originate from the gastrointestinal tract and lungs, with a consistently rising global incidence over recent decades. Hepatobiliary neuroendocrine neoplasms (HB-NENs), defined as primary NENs arising in the liver and biliary tract, are exceedingly uncommon, accounting for less than 0.5% of all NENs. Owing to their low incidence, atypical clinical presentations, and the paucity of large-scale datasets, no distinct World Health Organization (WHO) classification criteria have yet been established for these entities. Epidemiological characteristics and prognostic studies of HB-NENs remain extremely limited. Current prognostic evaluation relies predominantly on the American Join

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12662706 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature