Association of Plasma Inflammatory Proteins and Intracerebral Hemorrhage in Pediatric Brain Arteriovenous Malformations.

ABSTRACT:

Introduction

Brain arteriovenous malformations (bAVMs) are the leading cause of intracerebral hemorrhage (ICH) in children. Prior studies have implicated inflammation as a major contributor to bAVM pathogenesis and rupture, with increased inflammatory cell infiltration and interleukin protein levels reported in bAVM tissue. However, few studies have evaluated circulating inflammatory proteins as potential biomarkers for ICH in children with bAVMs.

Hypothesis

Plasma levels of inflammatory markers differ in pediatric patients with ruptured bAVMs compared to unruptured bAVMs.

Methods

This cross-sectional study included children with bAVMs (< 19 years old at presentation) evaluated at our institution between 2005 and 2022, who were enrolled in a prospective cohort study.

SUBMITTER: Chawla SA 

PROVIDER: S-EPMC12662739 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature