Intracranial Aneurysm Wall Phenotypes: Clinical, Morphological, and Hemodynamic Influences.

ABSTRACT:

Background

Intracranial aneurysm (IA) wall remodeling remains a critical yet poorly understood process despite extensive research into clinical, morphological, and hemodynamic determinants of IA formation, growth, and rupture. This study aimed to systematically characterize IA wall phenotypes-thin walled, thick walled, and heterogeneous-and to identify clinical, morphological, and hemodynamic determinants associated with these categories using intraoperative imaging and advanced computational analyses.

Methods

Intraoperative video recordings allowed for detailed annotation of wall regions, classifying distinct areas as red-translucent-acellular (thin) or white-hyperplastic/fibrotic and yellow-atherosclerotic (thick), along with associated blebs. Based on these observations,

SUBMITTER: Karnam Y 

PROVIDER: S-EPMC12662757 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature