Treatment outcomes of bedaquiline-resistant tuberculosis: a retrospective and matched cohort study.

ABSTRACT:

Background

Rising prevalence of bedaquiline resistance undermines benefits from this life-saving drug for rifampicin-resistant tuberculosis (RR tuberculosis). Despite increasing awareness, patient-level outcomes for bedaquiline-resistant tuberculosis have not been well characterised and case management has been poorly defined.

Methods

We did a retrospective cohort study of bedaquiline-resistant tuberculosis with matched RR tuberculosis controls at a tuberculosis referral hospital in East London, South Africa. Cases included patients aged 13 years or older with a phenotypic bedaquiline-resistant Mycobacterium tuberculosis isolate identified between Jan 1, 2018 and June 30, 2023. Controls with confirmed bedaquiline-susceptible tuberculosis, matched 1:1 by baseline culture stat

SUBMITTER: Mdlenyani L 

PROVIDER: S-EPMC12662777 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature