Identification of Key Biomarkers for Systemic Lupus Erythematosus Progression and Therapy Response: A Bulk RNA-Sequencing-Based Bioinformatics Study.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs and has a higher prevalence in women of reproductive age. The increasing global incidence of this disease poses a significant public health challenge. Current diagnostic methods are delayed because of nonspecific clinical manifestations and the limited specificity of available tests. Furthermore, conventional treatments frequently exhibit considerable side effects and fail to achieve complete disease control in many patients. Therefore, identifying novel diagnostic biomarkers and treatment targets is imperative. This study integrated transcriptomics, protein interaction analysis, and immunological infiltration assays to identify and confirm key biomarkers in SLE.

Methods

SUBMITTER: Huang L 

PROVIDER: S-EPMC12662787 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature