Preliminary Establishment of a Method and System for Detecting Neural Tumor Boundaries Based on Optical Coherence Tomography.

ABSTRACT: Surgical intervention is vital for treating neural system tumors, with precise intraoperative determination of tumor boundaries crucial for safe and effective surgery. Optical coherence tomography (OCT), offering noninvasive, real-time imaging, presents a promising solution. This study developed a swept-source OCT system using a 1310 nm wavelength laser, enhanced by microelectromechanical systems technology for improved scanning accuracy. Neural tumor specimens and peritumoral tissues were analyzed, alongside evaluations in animal models, including rats and mice with gliomas, schwannomas, and meningiomas, to assess the system's real-time surgical application. Results revealed significantly lower light attenuation in human glioma samples than in peritumoral tissues (p = 0.019), with

SUBMITTER: Li J 

PROVIDER: S-EPMC12662810 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature