Prognostic impact of primary tumor resection and nomogram development for survival prediction in colonic neuroendocrine carcinoma patients with liver metastasis: a SEER database-based study.

ABSTRACT:

Objective

This study aimed to investigate the prognostic impact of primary tumor resection in colonic neuroendocrine carcinoma (NECs) patients with liver metastasis, compare survival outcomes between left- and right-sided tumors, and develop a nomogram for predicting overall survival (OS) in this population.

Methods

Data from 449 colonic NECs patients with liver metastasis (2010-2021) were extracted from the SEER database. Patients were stratified by primary tumor location (left vs. right colon) and surgical resection status. Propensity score matching (PSM) was applied to balance the groups and subsequently investigate survival differences between them. Survival differences were analyzed using Kaplan-Meier curves and Cox regression. A nomogram integrating independent prognos

SUBMITTER: Chen J 

PROVIDER: S-EPMC12662923 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature