Diagnostic and prognostic value of myocardial flow reserve quantification with single photon emission computed tomography - a systematic review and meta-analysis.

ABSTRACT:

Background

Myocardial flow reserve (MFR), derived from dynamic single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), offers quantitative insight into coronary physiology and may overcome limitations of conventional semi-quantitative SPECT. We aimed to systematically review and meta-analyse the diagnostic accuracy and prognostic value of SPECT-derived MFR in comparison with invasive coronary angiography (ICA), PET-MPI, and long-term patient outcomes.

Results

A comprehensive literature search was done in scientific databases for studies comparing SPECT-derived MFR in patients with known or suspected coronary artery disease to ICA, PET-MPI, or ≥ 12-month follow-up for major adverse cardiac events. A meta-analysis was conducted using random-effec

SUBMITTER: Baksa B 

PROVIDER: S-EPMC12662936 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature