Overexpression of Sterol Regulatory Element-binding Transcription Factor 2 is associated with an adverse prognosis in cytogenetically normal acute myeloid leukemia.

ABSTRACT:

Background

Cytogenetically normal acute myeloid leukemia (CN-AML), the most heterogeneous subgroup, requires molecular markers for effective management. Recent studies have highlighted abnormal lipid metabolism as a critical feature driving AML progression, and Sterol Regulatory Element-Binding Factor 2 (SREBF2) - a key regulator of cholesterol metabolism - orchestrates this process by controlling genes involved in sterol biosynthesis and uptake to maintain cellular cholesterol homeostasis. Nevertheless, the prognostic value of SREBF2 in CN-AML remains incompletely understood, necessitating further investigation to clarify its mechanistic role and clinical impact.

Methods

We explored the prognostic implications of SREBF2 expression in two independent large-scale CN-AML patie

SUBMITTER: Shan R 

PROVIDER: S-EPMC12662961 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature