Investigating the potential anti-cancer mechanism for thyroid cancer: Role of Herba Epimedii via network pharmacology approach.

ABSTRACT:

Objective

To investigate the effective ingredients, crucial molecular targets, and the underlying molecular mechanisms associated with Herba Epimedii (HE) that exhibits anti-cancer effects for treating thyroid cancer (TC) using the network pharmacology approach.

Methods

The Traditional Chinese Medicine Systems Pharmacology (TCMSP) public database was analysed to identify the major bioactive ingredients and target proteins associated with HE. The Human Gene (Gene Cards) database, National Center for Biotechnology Information (NCBI) gene database, and Online Mendelian Inheritance in Man (OMIM) databases were analyzed to search for the disease targets of TC. Based on the overlapped results between HE putative targets and TC targets, the "compound-disease-target" network and a p

SUBMITTER: Wang X 

PROVIDER: S-EPMC12663004 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature