Relationship between body mass index, gray matter volume and peripheral inflammation in patients with post-COVID condition.

ABSTRACT:

Background

Obesity, a condition associated with low-grade peripheral inflammation, is an independent risk factor for severe COVID-19 and has been linked to structural brain alterations. Given that post-COVID condition (PCC) is also associated with structural brain abnormalities and lingering immunological alterations, this study aimed to assess whether obesity contributes to these neural and immunological differences in PCC patients.

Methods

We investigated a previously established cohort of PCC patients (n = 61), recruited between April 2021 and June 2022. Whole-brain comparison of gray matter volume (GMV) was conducted by voxel-based morphometry (VBM). Obesity, as measured by body mass index (BMI), as well as age, sex, and total intracranial volume (TIV), were included as

SUBMITTER: Claaß LV 

PROVIDER: S-EPMC12663082 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature