Comparison of different propofol target-controlled infusion concentrations in children with autism spectrum disorder undergoing magnetic resonance imaging.

ABSTRACT: This study aimed to compare the safety and efficacy of two target-controlled infusion (TCI) concentrations of propofol for sedation during cranial functional magnetic resonance imaging (fMRI) in children with autism spectrum disorder (ASD). A total of 120 preschool children with ASD scheduled for fMRI between January 2021 and July 2023 were enrolled and randomized into two groups: a low-concentration group (2.0 µg/mL, n = 60) and a high-concentration group (2.5 µg/mL, n = 60). Vital signs, sedation parameters, and adverse events were meticulously recorded to assess outcomes. The first-time sedation success rate was high and comparable between the 2.0 group and the 2.5 group (91.67% vs. 96.67%, p = 0.439). However, the 2.5 group demonstrated a significant reduction in mean systolic blood pr

SUBMITTER: Li H 

PROVIDER: S-EPMC12663107 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature