Predicting colorectal cancer survival by combined c-reactive protein and tumor immune score.

ABSTRACT: We evaluated the joint relationship of post-operative C-reactive protein (poCRP) and a tumor immune-cell-score (IS) with overall survival (OS) and CRC-specific survival (CSS) in 680 colorectal cancer (CRC) patients recruited in Germany. CRP was assessed post-surgery while IS was derived from CD3 + /CD8+ cell densities in tumor tissue. Patients were categorized into four C-Reactive protein-Immune cell Score (CRIS) groups: CRIS-1 (CRP-low/IS-high), CRIS-2 (CRP-low/IS-low), CRIS-3 (CRP-high/IS-high), and CRIS-4 (CRP-high/IS-low). Associations of CRIS with survival were assessed using Cox regression, and quantified by hazard ratios with 95% confidence intervals (HR, 95%CI). Subgroup analysis by presence of non-metastatic disease and time of blood draw in relation to adjuvant chemotherapy were

SUBMITTER: Gwenzi T 

PROVIDER: S-EPMC12663125 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature