Design of Cysteine Functional Polyesters through Michael Addition.

ABSTRACT: The use of amino acid molecules to tailor polymer properties is gaining traction in the field of biomedical applications like tissue engineering. Following this trend, in this work, L-cysteine (Cys) and N-acetyl-L-cysteine (NAC) were used to modify linear polyesters of butenedioic acid, specifically polymaleates and polyfumarates, via thio-Michael addition. The covalent attachment of amino acids via their thiol groups was evidenced by NMR and FT-IR analysis. NMR-based calculations also revealed that polymaleates showed a higher degree of addition (AD) than polyfumarates, with nearly 100% AD achieved using Cys. Further characteristics of the thermal properties and solubility of the obtained adducts revealed that polymaleates are more promising for such applications, as they showed high ther

SUBMITTER: Chroszcz-Porebska M 

PROVIDER: S-EPMC12663126 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature