Alterations in the gastric and small intestinal microbiota of mice exposed to short-term and long-term hypoxia.

ABSTRACT: Tens of millions of people worldwide travel to high-altitude regions (> 2500 m) every year for short-term work, tourism and pilgrimage. Hypoxia, resulting in a range of gastrointestinal disorders, is a significant physiological challenge in high-altitude environments. The gastrointestinal microbiota is closely linked to the mucosal barrier and our previous research found that hypoxia-induced mucosal injury mainly occurs in stomach and small intestine. This study aimed to characterize the temporal dynamics of gastric and small intestinal microbiota by directly analyzing the luminal contents to elucidate site-specific microbial alterations and their potential role in mucosal damage under hypoxic conditions. C57BL/6 J mice were randomly assigned to four groups: normoxic control, 1-day hypoxic

SUBMITTER: Liao X 

PROVIDER: S-EPMC12663162 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature