Noradrenergic modulation of pheromone-induced odor learning and brain activation in newborn rabbits.

ABSTRACT: Learning maternal odors is crucial for mammalian newborns, who must locate the mother's nipples to survive. In the newborn rabbit, the mammary pheromone (MP) present in the milk not only allows the pups to locate the nipples, but also promotes associative memory of neutral odorants. The noradrenergic system modulates neonatal learning in humans and rodents, but its role in newborn rabbits has never been investigated. Intraperitoneal injection of propranolol, a β-adrenoceptors antagonist, blocked acquisition, but not memory consolidation or retrieval, of MP-induced odor memory. Moreover, gene expression analyses revealed that propranolol attenuated c-Fos neuronal activation induced by odor learning in the olfactory bulb and to a lesser extent in the anterior piriform cortex, but not in the

SUBMITTER: Ducourneau EG 

PROVIDER: S-EPMC12663163 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature