Ultrasensitive electrochemical biosensor based on MXene quantum dots for prostate cancer biomarker detection.

ABSTRACT: Prostate cancer (PSA) is among the leading causes of men's deaths worldwide and needs extremely sensitive and cost-effective diagnostic tools. In this study, an electrochemical immunosensor enhanced by polyaniline-loaded MXene quantum dots and gold nanoparticles (PANI@Ti₃C₂ MXene Quantum dots-Au NPs) was constructed for highly sensitive prostate-specific antigen (PSA) detection at femtogram levels. The sensor employs V₂C MXene quantum dots gold-nanoparticle-decorated as signal tags to remarkably enhance electron transfer efficiency and detection sensitivity. A sandwich immunoassay strategy using MXene quantum dots gave superior selectivity and quantitation accuracy of PSA. The optimized immunosensor exhibited a large linear detection range of 2 fg mL^-

SUBMITTER: Safarpoor M 

PROVIDER: S-EPMC12663174 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature