USP13 dictates Ran turnover and vulnerability to ferroptosis in diffuse large B cell lymphoma (DLBCL).

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is one of the most common and lethal B-cell malignancies worldwide, with high relapse rate after standard treatment, and the relapsed cases are often difficult to treat. Ubiquitination has a pivotal role in cellular protein homeostasis and tumorigenic deubiquitinases (DUBs) stabilize oncoproteins during carcinogenesis. In this study, we have identified USP13 as one of the abnormally-overexpressed and stage-related DUBs in DLBCL critical to disease pathogenesis. Employing LC-MS/MS, Ran GTPase was characterized as potential substrate of USP13, with the interaction between Ran and USP13 modeled by Alphafold3. USP13 co-overexpressed, co-localized and correlated with Ran at protein level in DLBCL patient samples and cell lines. Pharmacological inhibition an

SUBMITTER: Qiao X 

PROVIDER: S-EPMC12663190 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature