Limited predictive value of preoperative nigrosome integrity for motor outcomes in Parkinson's disease deep brain stimulation.

ABSTRACT: Nigrosome-1, a substructure in the dorsolateral substantia nigra, is characterized by the "swallow tail sign" (STS)-a dorsolateral nigral hyperintensity (DNH)-on susceptibility-weighted MRI in healthy individuals. Loss of the STS reflects degeneration of nigrosome-1 and serves as a recognized diagnostic marker for Parkinson's disease (PD). However, its value in predicting disease severity and deep brain stimulation (DBS) outcomes remains unclear. We retrospectively analyzed 27 PD patients who underwent 3 T susceptibility map-weighted imaging (SMWI) derived from quantitative susceptibility mapping (QSM) prior to DBS. Nigrosome integrity was graded on a four-point scale, and patients were grouped as fully abnormal (Grade 4) or non-fully abnormal (Grades 1-3). No significant group differences

SUBMITTER: Hu CK 

PROVIDER: S-EPMC12663206 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature