Long COVID: lung pathophysiology and its relationship with cognitive dysfunction.

ABSTRACT: Post-acute sequelae of COVID-19 (Long COVID) includes physical and cognitive symptoms that can last long after acute infection. Links between lung pathophysiology and cognitive dysfunction in Long COVID remain largely unexplored. Long COVID participants were recruited from a post-COVID-19 clinic. Participants completed Patient-Reported Outcomes Measurement Information System (PROMIS) symptom questionnaires for Sleep Disturbance, Anxiety, Depression, and Cognitive Function, the National Institute of Health Toolbox Cognition Battery (NIHTB-CB), pulmonary function tests (spirometry, diffusion capacity of the lung), structural and functional brain magnetic resonance imaging (MRI), and ¹²⁹Xe MRI for ventilation and regional pulmonary gas exchange evaluation, at the same study visit.

SUBMITTER: Staab KR 

PROVIDER: S-EPMC12663264 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature