Development of intestinal tissue-resident T cells in early-life mice before and after weaning.

ABSTRACT: Intestinal tissue-resident T cells have been poorly characterized during early-life. Here, we phenotypically characterized tissue-resident (intravascular staining negative) CD4⁺ and CD8α⁺ T cells in spleen and intestine (lamina propria and intraepithelial lymphocytes), in suckling and juvenile mice before and after weaning, respectively. While minor changes were observed in spleen T cells, significant changes in tissue-resident T cells frequency and phenotype were identified after weaning. Although differences were seen between CD4⁺ and CD8α⁺ T cells in lamina propria and intraepithelial lymphocytes, in general, an increase of CCR7^- CD44^hi, CD69⁺, CD103⁺, and P2X7R⁺ tissue-resident T cells we

SUBMITTER: Montenegro C 

PROVIDER: S-EPMC12663277 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature