Unique response of polysulfide in serum albumin to oxidative stress.

ABSTRACT: Supersulfide species have been identified as molecules that have catenated sulfur atoms as persulfides (R-SSH) and polysulfides (R-SS_nH). The physiological activities of intracellular supersulfides have been widely studied, but little is known about the role of supersulfides in extracellular biological fluids. We therefore analyzed the pathological changes and oxidative stress responses of the reduced and oxidized forms of polysulfides in the plasma of patients with diabetic nephropathy. We measured the reduced and oxidized forms of polysulfide with elimination of sulfides using dithiothreitol and ascorbic acid plus alkali conditions, respectively. Oxidation decreased oxidized forms of polysulfide and further polysulfide in human serum albumin, increasing its antioxidative activ

SUBMITTER: Ikeda-Imafuku M 

PROVIDER: S-EPMC12663333 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature