Retinal alterations resemble brain pathology in a rat model of Parkinson's disease induced by intranigral infusion of α-synuclein oligomers.

ABSTRACT: Parkinson's disease (PD) is a debilitating neurodegenerative synucleinopathy, characterized by dopaminergic degeneration, pathological deposition of alpha-synuclein (α-Syn), and neuroinflammation in both motor regions of the midbrain and non-motor areas of the cortex. Despite its motor-centric characterization, visual disturbances such as hallucinations, diplopia, altered contrast sensitivity and retinal abnormalities are well-documented non-motor changes of PD. While this evidence points to neuropathological processes in PD that extend beyond the brain, the neuropathological basis of retinal dysfunction and the role of α-Syn remain poorly investigated. Given the central neuropathological role of α-Syn in the PD brain, we assessed whether the retina is affected in a translational rat model

SUBMITTER: Burgaletto C 

PROVIDER: S-EPMC12663455 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature