Suramin protects against chronic stress-induced neurobehavioral deficits via cGAS-STING/NF-κB suppression.

ABSTRACT: Prolonged exposure to stress alters brain pathophysiology by increasing inflammation leading to cellular and molecular dysfunction and initiation of neurobehavioral changes like anxiety, depression and cognitive impairment. Various signaling pathways and downstream cascades modulate the inflammatory responses within the Central Nervous System (CNS), notably cGAS-STING pathway and Nuclear factor kappa B (NF-κB) signaling are majorly affected. The present research aims to assess the consequence of modulation of cGAS with suramin in chronic unpredictable stress (CUS), and examining the impact on neurobehavioral alterations. For evaluating the impact of CUS and pharmacological interventions on neurobehavioral changes, Swiss albino mice of either sex were exposed to various stressors for 8 week

SUBMITTER: Sharma O 

PROVIDER: S-EPMC12663477 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature