An oncolytic herpesvirus expressing a CXCR4 antagonist interferes with glioblastoma cells' stemness features and migration.

ABSTRACT: Glioblastoma (GBM) is one of the most aggressive brain tumors. Despite the standard therapy, the survival from diagnosis remains dramatically low, especially due to tumor recurrence. Glioblastoma stem-like cells (GSCs) have been implicated in this tumor relapse, e.g., based on their capacity to escape the tumor and to migrate through the brain via CXCR4-dependent mechanisms. CXCR4 regulates biological features associated with tumor progression, including self-renewal, migration, and radio resistance. Importantly, its expression correlates with severity and poor prognosis of several cancers including GBM. The CXCR4/CXCL12 pathway therefore appears as an interesting potential therapeutic target. We have generated an oncolytic herpes simplex virus (oHSV) expressing HA-P2G, a mutated form of C

SUBMITTER: D'arrigo P 

PROVIDER: S-EPMC12663512 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature