SKP2 protein as a prognostic biomarker for glioma and promotes tumor progression by regulating the cell cycle.

ABSTRACT: SKP2 (S-phase kinase-associated protein 2) plays an important role in the regulation of the cell cycle, tumorigenesis, progression, and metastasis. However, its functional role in gliomas is currently unclear. This study aimed to investigate the relationship between SKP2 and the progression of gliomas, and its effects on the glioma cell cycle. The relationship between SKP2 expression levels and clinical characteristics of gliomas was explored in our datasets. Kaplan-Meier analysis and COX regression were conducted to evaluate the prognostic role of SKP2. Differentially expressed genes were identified between high and low SKP2 groups. The function and related mechanisms of SKP2 were evaluated based on Gene Ontology and Gene Set Enrichment Analysis. LASSO-Cox was used to screen the variables

SUBMITTER: Guan L 

PROVIDER: S-EPMC12663543 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature