Mapping key mitochondrial genes in Alzheimer's disease through human tissue and iPSC derived neurons.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurodegenerative condition that has become a global health challenge due to an aging world population and no available effective treatment. Mitochondrial dysfunction plays a crucial role in the development of AD due to its critical role in neuronal survival and function. However, the specific mitochondrial genes and pathways involved in AD pathogenesis remain poorly defined. In this study, we incorporated seven AD human postmortem and three AD iPSC-derived neurons (iNs) gene expression datasets to identify mitochondria-related Differentially Expressed Genes (mitoDEGs) between AD and control. The Gene Ontology (GO) analysis is conducted to investigate the AD biological mechanisms, and a random forest model is developed to assess how well the key mi

SUBMITTER: Dong D 

PROVIDER: S-EPMC12663557 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature