Previous exposure to traumatic brain injury alters acute stress responses in mice.

ABSTRACT: Acute stress (AS) exposure and traumatic brain injury (TBI) have a high prevalence and result in emotional and behavioral impairments. In fact, TBI is a leading cause of mortality in young adults and survivors cope with neuropsychological sequelae including memory decline, addiction, anxiety and compromised stress responses. So far, the interaction of psychological stress with previous TBI is poorly understood. Herein, the impact of a previous TBI on AS responsiveness was investigated. For this, a model of mild TBI and restraint AS was employed and mice were grouped into sham, TBI alone, AS alone and TBI + AS cohorts. The impact of an initial TBI on subsequent AS was analyzed by immediate early gene (IEG) and neuroinflammatory gene expression as well as proteomics. In addition, behavioral

SUBMITTER: Gu H 

PROVIDER: S-EPMC12663578 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature