Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression.

ABSTRACT: There are substantial care gaps in optimizing treatment response for bipolar depression given, at best, a modicum of benefit from antidepressant treatment and, in contrast, a substantial cardiometabolic burden associated with regulatory-approved antipsychotic treatment. Lamotrigine (LGT) is an anticonvulsant with an evidence base in both epilepsy and bipolar disorder (BD), in particular bipolar depression "stabilizing from down under." There is a well-established bidirectional relationship between BD and epilepsy. Recognizing the complex interplay between mood, diet, and energy metabolism, lifestyle interventions have emerged as an adjunctive therapeutic approach in BD. Among these, therapeutic ketosis, with century-old evidence base in epilepsy, has regained new interest as a promising ad

SUBMITTER: Ali DN 

PROVIDER: S-EPMC12663626 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature