Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer.

ABSTRACT:

Background and purpose

Although cone beam computed tomography (CBCT) enables online adaptive radiotherapy, its CT number accuracy may be insufficient for online adaptive proton therapy (OAPT). We compared proton dose distributions calculated directly on CBCT with calculations using additional CBCT image-processing methods in prostate cancer.

Materials and methods

Retrospective proton plans were created for 10 prostate patients originally treated with 5-fraction online adaptive photon radiotherapy using CBCT. These plans were forward-calculated on each CBCT with four different approaches: (1) the clinical CBCT with a dedicated CT number calibration, (2) CBCT with histogram correction, (3) CT deformed to the CBCT, and (4) deformed CT with an air-cavity correction. Additionally

SUBMITTER: Bobic M 

PROVIDER: S-EPMC12663649 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature