Red blood cell-activated antifreeze metal-organic framework armor for cryopreservation.

ABSTRACT: Red blood cell (RBC) cryopreservation is essential for maintaining ex vivo biological function and enabling long-term storage. However, the fragile nature of RBCs makes them highly susceptible to hemolysis during freezing and thaw cycles, limiting their widespread application. Here, a metal-organic framework (MOF)-based armor has been developed in a physiological environment, which enables one-step in situ encapsulation and unloading of RBCs. This MOF armor, functioning as a nano-bio interface, effectively shields RBCs from cryo-induced damage while preserving their native oxygen-carrying function. The MOF-armored RBCs not only inhibit ice recrystallization by restricting water molecule movement within the porous MOF structure but also serve as a "catalyst" to induce the smoothing of the i

SUBMITTER: Li X 

PROVIDER: S-EPMC12663683 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature