Non-classical protein secretion in bacteria.

ABSTRACT:

Background

We present an overview of bacterial non-classical secretion and a prediction method for identification of proteins following signal peptide independent secretion pathways. We have compiled a list of proteins found extracellularly despite the absence of a signal peptide. Some of these proteins also have known roles in the cytoplasm, which means they could be so-called "moon-lightning" proteins having more than one function.

Results

A thorough literature search was conducted to compile a list of currently known bacterial non-classically secreted proteins. Pattern finding methods were applied to the sequences in order to identify putative signal sequences or motifs responsible for their secretion. We have found no signal or motif characteristic to any majority of the

SUBMITTER: Bendtsen JD 

PROVIDER: S-EPMC1266369 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature