Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing <i>TNNT2</i> sarcomeric variants.

ABSTRACT: Cardiomyocytes endure physical stress from the myocardium environment while generating their own mechanical strains. The force generated by sarcomeres is transmitted both longitudinally to adjacent sarcomeres and laterally to the cytoskeleton via intermediate filaments. This mechanical stimulus impacts other organelles, including the nucleus, thus playing a vital role in sensing and signaling nuclear adaptations. However, there is limited understanding of how changes in cardiac contractility affect nuclear mechanics. Here, we sought to investigate the effects of hyper- and hypo-contractility in nuclei of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) bearing TNNT2 pathogenic variants associated with hypertrophic (HCM) or dilated (DCM) cardiomyopathies. Transc

SUBMITTER: Coscarella IL 

PROVIDER: S-EPMC12663735 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature