Protective role of soluble CD52 in obesity-associated steatotic liver disease and glucose dysregulation in mice.

ABSTRACT:

Objectives

Soluble CD52 (sCD52) derived from activated CD4⁺ T cells regulates T cell immunity under autoimmune conditions; however, its role in obesity-associated chronic inflammation and glucose metabolism remains unclear. Therefore, we herein investigated the significance of CD52 in obesity.

Methods

CD52-knockout mice (KO) and their wild-type littermates were fed a high-fat diet (HFD) for 12 weeks and analyzed.

Results

sCD52 preferentially suppressed chronic liver inflammation and protected against impaired glucose tolerance and metabolic dysfunction-associated steatotic liver disease (MASLD) in obesity. No significant differences were observed in weight gain or energy metabolism in KO mice; however, glucose metabolism was impaired. A histological examina

SUBMITTER: Miyazawa Y 

PROVIDER: S-EPMC12663843 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature