Red Blood Cell Distribution and Volume Changes at Capillary Junctions in the Living Human Retina.

ABSTRACT:

Purpose

To characterize red blood cell (RBC) distribution and associated changes in cell size at capillary junctions in the human neural retina.

Methods

Cell-resolved blood flow across 60 capillary junctions in the retina of 6 healthy human subjects was measured, using flood-illumination adaptive optics at 200 to 400 fps. Several empirical RBC partitioning models, including a widely used model developed by Pries et al., were compared for predictive accuracy.

Results

We provide updated Pries model coefficients to suit human retinal capillaries. We also propose a simpler linear model that predicts RBC flow distribution based solely on the share of blood flow received by a branch, without reference to the main vessel. Cell size analysis revealed that the average RBC volu

SUBMITTER: Ding Y 

PROVIDER: S-EPMC12663880 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature