Sirtuin 6 is a histone delactylase.

ABSTRACT: Histone lactylation (Kla) is a post-translational modification (PTM) that is derived from metabolic lactate. Histone Kla has been extensively studied in the field of inflammation resolution and macrophage polarization but has also been implicated in diverse cellular processes including differentiation, various wound repair phenotypes, and oncogenesis in several cancer models. While mechanistic connections between histone Kla and transcriptional changes have been studied in very limited contexts, general mechanistic details describing how regulation of gene expression by histone Kla occurs are scarce. It is hypothesized that histone Kla may be installed either through nonenzymatic means or by acetyltransferases like p300, and it is known that Class I HDACs and Sirtuins 1 to 3 can remove his

SUBMITTER: Nickel GA 

PROVIDER: S-EPMC12664031 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature