Spatiotemporal dynamics of mucosa-associated <i>Lactobacillus</i> along the small intestine and its response to 2'-fucosyllactose and galacto-oligosaccharides in piglets.

ABSTRACT: Early-life colonization of Lactobacillus in the gut is crucial for immediate and lifelong health. The intestinal mucosa is a key interface of host-microbiota interaction, but the colonization patterns of Lactobacillus within this niche remain unclear. In this study, nine newborn piglets per litter (ten litters total) were randomly assigned (three piglets per group per litter; n = 30 per group across all litters) to receive daily oral doses of 2'-fucosyllactose (2'-FL, 100 mg/(kg·d)), galactooligosaccharides (GOS, 1 g/(kg·d)), or saline (control) during the 21 day suckling period. The results revealed significant age-associated shifts in Lactobacillus composition, with the higher Lactobacillus abundance observed during the suckling period and decreasing af

SUBMITTER: Fan W 

PROVIDER: S-EPMC12664059 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature