Effects of the α-ketoglutaric acid on the performance, hair follicle development and antioxidant capacity of Rex rabbits.

ABSTRACT: The aim of this study was to investigate the effects of α-ketoglutaric acid (AKG) supplementation on hair follicle development and to evaluate the effects on performance and antioxidant capacity in Rex rabbits. The mechanism was explored in an in vitro model and validated in an animal trial. Firstly, dermal papilla cells (DPCs) line was cultured with AKG as an in vitro model. Next, a total of 160 Rex rabbits (120-d-old, body weight 2473.20 ± 17.08 g) were divided into 4 groups with 40 rabbits in each group (20 male and 20 female) and fed with 0, 0.5%, 1.0% and 1.5% AKG diets for 35 d. The result showed that 6 mmol/L AKG significantly promoted cell proliferation (P < 0.001), reduced the proportion of cells in the synthesis (S) phase and increased the gap 2 (G2) phase (P < 0.01

SUBMITTER: Wang X 

PROVIDER: S-EPMC12664061 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature