A comprehensive study on the dual species biofilm formation of clinical <i>Staphylococcus aureus</i> and <i>Candida albicans</i> strains from the same origins.

ABSTRACT: Biofilms, complex microbial communities that enhance pathogen survival in hostile environments, are integral to chronic infections and often exhibit polymicrobial interactions that influence disease outcomes. Among these, Staphylococcus aureus and Candida albicans co-infections are of particular clinical significance due to their synergistic mechanisms, resulting in invasive and treatment-resistant infections. This study investigated the interaction dynamics of S. aureus and C. albicans in both planktonic and biofilm states, focusing on growth dominance, biofilm formation, and structural adaptations under different conditions. Results revealed that C. albicans dominated in planktonic co-culture, suppressing S. aureus growth, whereas biofilm conditi

SUBMITTER: Li Y 

PROVIDER: S-EPMC12664092 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature